SAFETY DATA SHEETS
According to the UN GHS revision 10
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 1,2,3,6-tetrahydrophthalic anhydride |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | CIS-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research use. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Zhongshan Greenrock Technology Co., Ltd. |
|---|---|
| Address | No. 138, Jinsan Avenue, Sanjiao Town, Zhongshan City, Guangdong Province, China |
| Telephone | +86-2087066781 |
| export@greenrockchem.com |
1.5 Emergency phone number
| Emergency phone number | +86-2087066781 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Serious eye damage, Category 1
Skin sensitization, Category 1
Respiratory sensitization, Category 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H318 Causes serious eye damage H317 May cause an allergic skin reaction H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H412 Harmful to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P284 [In case of inadequate ventilation] wear respiratory protection. P273 Avoid release to the environment. |
| Response | P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P317 If skin irritation or rash occurs: Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 1,2,3,6-tetrahydrophthalic anhydride | 1,2,3,6-tetrahydrophthalic anhydride | 85-43-8 | 201-605-4 | ≈ 99% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Half-upright position. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Do NOT induce vomiting.
4.2 Most important symptoms/effects, acute and delayed
Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist respirations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Activated charcoal is not effective . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination . Organic acids and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Powder, water spray, foam, carbon dioxide.
5.2 Specific hazards arising from the chemical
Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. (ERG, 2016)
5.3 Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: P2 filter respirator for harmful particles.
6.2 Environmental precautions
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: P2 filter respirator for harmful particles.
6.3 Methods and materials for containment and cleaning up
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. (Extra personal protection: P2 filter respirator for harmful particles.)
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Dry. Well closed.Separated from food and feedstuffs. Dry. Well closed.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Solid. Flakes. |
|---|---|
| Colour | White. |
| Odour | no data available |
| Melting point/freezing point | 104.4 °C. |
| Boiling point or initial boiling point and boiling range | 292.2 °C. Atm. press.:1 013 kPa. |
| Flammability | Combustible. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 156 °C. Atm. press.:1 013 hPa. |
| Auto-ignition temperature | 450 deg C |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | Slightly soluble in petroleum ether and ethyl ether; soluble in benzene |
| Partition coefficient n-octanol/water | log Pow = 1.29. Temperature:40 °C. |
| Vapour pressure | Ca. 0 hPa. Temperature:Ca. 20 °C.;Ca. 0 hPa. Temperature:Ca. 25 °C.;Ca. 0.015 hPa. Temperature:Ca. 50 °C. |
| Density and/or relative density | 1 355.4 kg/m³. Temperature:20 °C. |
| Relative vapour density | (air = 1): 5.3 |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Decomposes on contact with hot surfaces or flames. This produces corrosive fumes. Reacts with oxidants. Reacts with water. This produces heat and tetrahydrophthalic acid.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
Combustible when exposed to heat of flame.TETRAHYDROPHTHALIC ANHYDRIDE reacts exothermically with water. The reactions are usually slow, but can become violent when local heating accelerates their rate. Acid accelerates the rate of reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Reacts with oxidants. Reacts with water to produce heat and tetrahydrophthalic acid.
10.6 Hazardous decomposition products
When heated to decomposition it emits acrid smoke and fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - ca. 3 200 mg/kg bw.
- Inhalation: no data available
- Dermal: LD50 - rat (male/female) - > 2 000 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract.
STOT-repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - > 100 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 100 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 65.3 mg/L - 72 h.
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
no data available
12.3 Bioaccumulative potential
Based upon the rapid hydrolysis of structurally analogous phthalic anhydride(1), half-lives of 1.5 and 2.7 minutes(SRC) from rate constants of 6.9X10-3/sec(2) and 4.3X10-3/sec(3), respectively, biococentration of tetrahydrophthalic anhydride is not expected to be an important fate process(SRC).
12.4 Mobility in soil
Based upon the rapid hydrolysis of structurally analogous phthalic anhydride(1), half-lives of 1.5 and 2.7 minutes(SRC) from rate constants of 6.9X10-3/sec(2) and 4.3X10-3/sec(3), respectively, adsorption of tetrahydrophthalic anhydride is not expected to be an important environmental fate process(SRC).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2698 (For reference only, please check.) | IMDG: UN2698 (For reference only, please check.) | IATA: UN2698 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: TETRAHYDROPHTHALIC ANHYDRIDES with more than 0.05% of maleic anhydride (For reference only, please check.) | IMDG: TETRAHYDROPHTHALIC ANHYDRIDES with more than 0.05% of maleic anhydride (For reference only, please check.) | IATA: TETRAHYDROPHTHALIC ANHYDRIDES with more than 0.05% of maleic anhydride (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 8 (For reference only, please check.) | IMDG: 8 (For reference only, please check.) | IATA: 8 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 1,2,3,6-tetrahydrophthalic anhydride | 1,2,3,6-tetrahydrophthalic anhydride | 85-43-8 | 201-605-4 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2024 |
|---|---|
| Revision Date | July 15, 2024 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.For cis-isomer the CAS number is 935-79-5.
Any questions regarding this SDS, Please send your inquiry to export@greenrockchem.com
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.