SAFETY DATA SHEETS
According to the UN GHS revision 10
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | Morpholine |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 1,4-Oxazinan; Morpholine; MORPHOLINE,ACS |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research use. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Zhongshan Greenrock Technology Co., Ltd. |
|---|---|
| Address | No. 138, Jinsan Avenue, Sanjiao Town, Zhongshan City, Guangdong Province, China |
| Telephone | +86-2087066781 |
| export@greenrockchem.com |
1.5 Emergency phone number
| Emergency phone number | +86-2087066781 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Flammable liquids, Category 3
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Skin corrosion, Sub-category 1B
Acute toxicity - Category 4, Inhalation
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |    |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H226 Flammable liquid and vapour H302 Harmful if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H332 Harmful if inhaled |
| Precautionary statement(s) | |
| Prevention | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Storage | P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Morpholine | Morpholine | 110-91-8 | 203-815-1 | ≈ 99% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. See Notes.
Following skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
VAPOR: Irritating to eyes, nose and throat. If inhaled, will cause nausea, headache, or difficult breathing. LIQUID: Irritating to skin and eyes. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Use dry chemical, carbon dioxide, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full facepieces and are operated in a pressure-demand or other positive-pressure mode.
5.2 Specific hazards arising from the chemical
FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Irritating vapors are generated when heated. Vapor is heavier than air and may travel some distance to source of ignition and flash back. (USCG, 1999)
5.3 Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Spill handling: evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 35°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong oxidants and acids. Dry.Before entering confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. Morpholine must be stored to avoid contact with strong acids, such as nitric acid, and strong oxidizers, such as chlorine dioxide, bromine, nitrates, and permanganates, since violent reactions occur.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
TLV: 20 ppm as TWA; (skin); A4 (not classifiable as a human carcinogen).MAK: 36 mg/m3, 10 ppm; peak limitation category: I(2); pregnancy risk group: D.EU-OEL: 36 mg/m3, 10 ppm as TWA; 72 mg/m3, 20 ppm as STEL
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear face shield or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Liquid. |
|---|---|
| Colour | Colourless. |
| Odour | Characteristic amine |
| Melting point/freezing point | -4.9 °C. |
| Boiling point or initial boiling point and boiling range | 128.3 °C. Atm. press.:1 013 hPa. |
| Flammability | Class IC Flammable Liquid: Fl.P. at or above 73°F and below 100°F. |
| Lower and upper explosion limit/flammability limit | Lower flammable limit: 1.4% by volume; Upper flammable limit: 11.2% by volume |
| Flash point | 32 °C. Atm. press.:1 013.25 hPa. |
| Auto-ignition temperature | 255 °C. Atm. press.:1 013 hPa. |
| Decomposition temperature | no data available |
| pH | Strong base |
| Kinematic viscosity | dynamic viscosity (in mPa s) = 2.23. Temperature:20°C. |
| Solubility | Miscible with water |
| Partition coefficient n-octanol/water | log Pow = -2.55. Temperature:25 °C.;log Pow = -0.84. Temperature:25 °C. |
| Vapour pressure | 9.8 hPa. Temperature:20.3 °C. |
| Density and/or relative density | 1.001. Temperature:20 °C. |
| Relative vapour density | 3 (vs air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
1400 ppm [Based on 10% of the lower explosion limit for safety considerations even though the relevant toxicological data indicated that irreversible health efects or impairment of escape existed only at higher concentrations.]
Decomposes on burning. This produces toxic fumes of nitrogen oxides and carbon monoxide. The substance is a medium strong base. Reacts with strong oxidants. This generates fire hazard. Attacks plastics, rubber and coatings. Unstable if stored in copper or zinc containers.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
A very dangrous fire hazard when exposed to flame, heat, or oxidizers.MORPHOLINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Sensitive to moisture. Reacts readily with oxidizing agents (NTP, 1992).
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Violent reaction and fire may result when the product is mixed with oxidizing agents, such as perchlorates, nitrates, permanganates, chromates, nitric acid, halogens, peroxides, and some cleaning solutions containing acids.
10.6 Hazardous decomposition products
When heated to decomposition it emits highly toxic fumes of /nitric oxide/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - ca. 1 900 mg/kg bw.
- Inhalation: Inhalation Risk Test - rat (male/female) - Inhalation Risk Test.
- Dermal: LD50 - rabbit (male) - ca. 500 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of morpholine were available. There is inadequate evidence in experimental animals for the carcinogenicity of morpholine. Overall evaluation: Morpholine is not classifiable as to its carcinogenicity to humans (Group 3).
Reproductive toxicity
no data available
STOT-single exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes.
STOT-repeated exposure
The substance may have effects on the liver and kidneys.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - 180 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 45 mg/L - 48 h.
- Toxicity to algae: EC0 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 10 mg/L - 96 h.
- Toxicity to microorganisms: EC20 - activated sludge, domestic - > 1 000 mg/L - 30 min. Remarks:Respiration rate.
12.2 Persistence and degradability
AEROBIC: Morpholine, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Morpholine degraded 87% after 28 days with a 16 day lag period during an OECD Manometric Respirometry test using a sapromat system and 89% after a 16 day lag period using an oxitop system(2). However, it proved to be readily biodegradable in the 28-day OECD screening test and inherently biodegradable in a 31-day Zahn-Wellens test, exhibiting a final degradation level of >90% in both tests(3). An adaptation period of 7-20 days was required before degradation occurred. The final level of degradation was also >90% in a laboratory-scale wastewater treatment plant, but the adaptation period was 10-21 days(3).
12.3 Bioaccumulative potential
Bioconcentrationw were measured in carp over a 6 week period. With starting concentrations of 5 ppm and 0.5 ppm the measured bioconcentrations were less than 0.3 to 0.65 and less than 2.8 at morpholine, respectively(1). According to a classification scheme(2), these BCF ranges suggest the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The Koc of morpholine is estimated as 7.4(SRC), using a log Kow of -0.86(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that morpholine is expected to have very high mobility in soil. The pKa of morpholine is 8.49(4), indicating that this compound will almost entirely exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2054 (For reference only, please check.) | IMDG: UN2054 (For reference only, please check.) | IATA: UN2054 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: MORPHOLINE (For reference only, please check.) | IMDG: MORPHOLINE (For reference only, please check.) | IATA: MORPHOLINE (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 8 (For reference only, please check.) | IMDG: 8 (For reference only, please check.) | IATA: 8 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: I (For reference only, please check.) | IMDG: I (For reference only, please check.) | IATA: I (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Morpholine | Morpholine | 110-91-8 | 203-815-1 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2024 |
|---|---|
| Revision Date | July 15, 2024 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is suggested.The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Immediate administration of an appropriate inhalation therapy by a doctor, or by an authorized person, should be considered.
Any questions regarding this SDS, Please send your inquiry to export@greenrockchem.com
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.